期刊
ATHEROSCLEROSIS
卷 240, 期 1, 页码 3-9出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.atherosclerosis.2015.02.036
关键词
Atherosclerosis; Cardiovascular risk factors; Coronary artery calcium; P-selectin
资金
- MESA
- National Heart, Lung, and Blood Institute [N01 HC-95159, N01-HC-95160, N01-HC-95161, N01-HC-95162, N01-HC95163, N01-HC-95164, N01-HC-95165, N01-HC-95166, N01-HC95167, N01-HC-95168, N01-HC-95169, RR-024156]
- NHLBI [R01 HL98077, R01 HL088451, R01 HL069003, R01 HL081352]
Objective: P-selectin is a cellular adhesion molecule that has been shown to be crucial in development of coronary heart disease (CHD). We sought to determine the role of P-selectin on the risk of atherosclerosis in a large multi-ethnic population. Methods: Data from the Multi-Ethnic Study of Atherosclerosis (MESA), including 1628 African, 702 Chinese, 2393 non-Hispanic white, and 1302 Hispanic Americans, were used to investigate the association of plasma P-selectin with CHD risk factors, coronary artery calcium (CAC), intima-media thickness, and CHD. Regression models were used to investigate the association between P-selectin and risk factors, Tobit model for CAC, and Cox regression for CHD events. Results: Mean levels of P-selectin differed by ethnicity and were higher in men (P < 0.001). For all ethnic groups, P-selectin was positively associated with measures of adiposity, blood pressure, current smoking, LDL, and triglycerides and inversely with HDL. A significant ethnic interaction was observed for the association of P-selectin and prevalent diabetes; however, P-selectin was positively associated with HbA1c in all groups. Higher P-selectin levels were associated with greater prevalence of CAC. Over 10.1 years of follow-up, there were 335 incident CHD events. There was a positive linear association between P-selectin levels and rate of incident CHD after adjustment for traditional risk factors. However, association was only significant in non-Hispanic white Americans (HR: 1.81, 95% CI 1.07 to 3.07, P = 0.027). Conclusion: We observed ethnic heterogeneity in the association of P-selectin and risk of CHD. (C) 2015 Elsevier Ireland Ltd. All rights reserved.
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