期刊
ATHEROSCLEROSIS
卷 239, 期 2, 页码 629-633出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.atherosclerosis.2015.02.011
关键词
Nonalcoholic fatty liver disease; Obesity; Metabolic syndrome; Inflammation; Subclinical atherosclerosis
资金
- National Heart, Lung, and Blood Institute [R01 HL071739, N01-HC-95159, N01-HC-95165, N01 HC 95169]
- DIVISION OF EPIDEMIOLOGY AND CLINICAL APPLICATIONS [N01HC095165, N01HC095162, N01HC095159] Funding Source: NIH RePORTER
Introduction: We characterized the association of 3 metabolic conditions - obesity, metabolic syndrome, and nonalcoholic fatty liver disease (NAFLD) - with increased inflammation and subclinical atherosclerosis. Methods: We conducted cross-sectional analysis of 3976 participants from the Multi-Ethnic Study of Atherosclerosis (MESA) with adequate CT imaging to diagnose NAFLD. Obesity was defined as BMI >= 30 kg/m(2), metabolic syndrome by AHA/NHLBI criteria, and NAFLD using non-contrast cardiac CT and a liver/spleen attenuation ratio (L/S) < 1. Increased inflammation was defined as high sensitivity C-reactive protein (hsCRP) >= 2 mg/L and subclinical atherosclerosis as coronary artery calcium (CAC) > 0. We studied the association of a stepwise increase in number of these metabolic conditions (0-3) with increased inflammation and CAC, stratifying results by gender and ethnicity. Results: Mean age of participants was 63 (+/- 10) years, 45% were male, 37% white, 10% Chinese, 30% African American, and 23% were Hispanic. Adjusting for obesity, metabolic syndrome and traditional risk factors, NAFLD was associated with a prevalence odds ratio for hsCRP >= 2 mg/L and CAC > 0 of 1.47 (1.20 -1.79) and 1.37 (1.11-1.68) respectively. There was a positive interaction between female gender and NAFLD in the association with hsCRP >= 2 mg/L (p = 0.006), with no interaction by race. With increasing number of metabolic conditions, there was a graded increase in prevalence odds ratios of hsCRP >= 2 mg/L and CAC > 0. Conclusion: NAFLD is associated with increased inflammation and CAC independent of traditional risk factors, obesity and metabolic syndrome. There is a graded association between obesity, metabolic syndrome, and NAFLD with inflammation and CAC. (C) 2015 Elsevier Ireland Ltd. All rights reserved.
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