期刊
ATHEROSCLEROSIS
卷 241, 期 2, 页码 387-399出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.atherosclerosis.2015.05.035
关键词
Host-gut microbiota interactions; Mucosal immune system; Trimethylamine-N-oxide; Germ-free mice; Polyphenolic metabolites; Systems biology approach
资金
- Leducq Foundation
- Marie Curie fellowship [MC330381]
- [HL28481]
- [HL30568]
- [HL126753]
- [D094311]
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [P01HL028481, R01HL126753, P01HL030568] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES [DP3DK094311] Funding Source: NIH RePORTER
Recent studies have convincingly linked gut microbiota to traits relevant to atherosclerosis, such as insulin resistance, dyslipidemia and inflammation, and have revealed novel disease pathways involving microbe-derived metabolites. These results have important implications for understanding how environmental and genetic factors act together to influence cardiovascular disease (CVD) risk. Thus, dietary constituents are not only absorbed and metabolized by the host but they also perturb the gut microbiota, which in turn influence host metabolism and inflammation. It also appears that host genetics helps to shape the gut microbiota community. Here, we discuss challenges in understanding these interactions and the role they play in CVD. (C) 2015 Elsevier Ireland Ltd. All rights reserved.
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