期刊
SPINAL CORD
卷 48, 期 2, 页码 154-159出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/sc.2009.101
关键词
neurogenic bowel disorders; sacral nerve modulation; spinal cord lesion; constipation fecal incontinence
Study design: Retrospective study. Objectives: Efficacy and safety of sacral neuromodulation (SNM) in incomplete spinal cord-injured patients (SCIPs) affected by chronic neurogenic bowel symptoms (NBSs). Setting: Neurourology Department. Primary to tertiary care. Methods: Retrospective non-blinded study without controls. Thirty-nine SCIPs were submitted to temporary stimulation for NBS. Permanent implantation was carried out if both their NBSs improved and the Wexner questionnaire scores were reduced by at least 50% during the first stage compared with that at baseline. Outcome measures included episodes of fecal incontinence and number of evacuations per week, as well as the Wexner score and the Short Form 36 (SF-36) Health Survey questionnaire. Results: Twenty-three SCIPs were submitted to definitive SNM, maintaining their clinical benefits after permanent implantation with a median follow-up of 38 months. The length of time since neurological diagnosis to SNM therapy represents the only factor related to the success of the implantation, P<0.05. In subjects with constipation (12), the median number of evacuations shifted from 1.65 to 4.98 per week, whereas the Wexner score changed from 19.91 to 6.82 in the final checkup with P<0.05. In subjects with fecal incontinence (11), the median number of episodes per week in the final follow-up was 1.32 compared with 4.55 pre-SNM. The general and mental health of both groups was measured with the SF-36 questionnaire and consistently showed statistical improvement (P<0.05). Anorectal manometry showed no important variation compared with baseline. There were no major complications. Conclusions: SNM therapy should be considered for the treatment of NBS for select patients with incomplete spinal cord injury when conservative treatments fail. Spinal Cord (2010) 48, 154-159; doi: 10.1038/sc.2009.101; published online 11 August 2009
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