期刊
SPECTROSCOPY-AN INTERNATIONAL JOURNAL
卷 27, 期 5-6, 页码 463-496出版社
HINDAWI LTD
DOI: 10.1155/2012/848360
关键词
Infrared spectroscopy; Raman spectroscopy; medical diagnosis; cytopathology; histopathology; cellular imaging; multivariate methods
资金
- National Institutes of Health [CA 090346, CA 111330, CA 153148]
This paper summarizes the progress achieved over the past fifteen years in applying vibrational (Raman and IR) spectroscopy to problems of medical diagnostics and cellular biology. During this time, a number of research groups have verified the enormous information content of vibrational spectra; in fact, genomic, proteomic, and metabolomic information can be deduced by decoding the observed vibrational spectra. This decoding process is aided enormously by the availability of high-power computer workstations and advanced algorithms for data analysis. Furthermore, commercial instrumentation for the fast collection of both Raman and infrared microspectral data has rendered practical the collection of images based solely on spectral data. The progress in the field has been manifested by a steady increase in the number and quality of publications submitted by established and new research groups in vibrational biological and biomedical arenas.
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