期刊
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
卷 117, 期 -, 页码 798-800出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.saa.2013.09.064
关键词
Curcumin; A beta; Metals; Fibrillization; CD; AFM
类别
资金
- Department of Science and Technology, Govt. of India, under the SERC-Fast-track Young Scientist Scheme
The effect of Curcumin on Cu(II) and Zn(II) induced oligomerization and protofibrillization of the amyloid-beta (A beta) peptide has been studied by spectroscopic and microscopic methods. Curcumin could significantly reduce the beta-sheet content of the peptide in a time dependent manner. It also plays an antagonistic role in beta-sheet formation that is promoted by metal ions like Cu(II) and Zn(II) as observed by Circular Dichroism (CD) spectroscopy. Atomic force microscopic (AFM) images show that spontaneous fibrillization of the peptide occurs in presence of Cu(II) and Zn(II) but is inhibited on incubation of the peptide with Curcumin indicating the beneficial role of Curcumin in preventing the aggregation of A beta peptide. (C) 2013 Elsevier B.V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据