期刊
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
卷 110, 期 -, 页码 419-424出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.saa.2013.03.036
关键词
Resonance light scattering; DNAzyme; Gold nanoparticles; Uranyl
类别
资金
- National Natural Science Foundation of China [21177052]
- Science and Technology Program of Hunan Province in China [2010SK3039]
- Construct Program of the Key Discipline (Public Health and Preventive Medicine) in Hunan Province
A resonance light scattering (RLS) method has been developed using a uranyl (UO22+) specific DNAzyme and gold nanoparticles (AuNPs). In this strategy, the cleavage of the substrate strand (SDNA) of DNAzyme results in releasing a shorter duplex in the presence of UO22+, leading to the aggregation of AuNPs and the increase of RLS intensity. The response signals linearly correlated with the concentration of UO22+ over the range of 1.36 x 10(-8)-1.50 x 10(-7) mol L-1. The limit of detection (LOD) is 4.09 x 10(-9) mol L-1. The method has excellent selectivity and higher sensitivity. It could provide a promising potential for the detection of metal ions, and be benefit to extend the application of RLS method. (C) 2013 Elsevier B.V. All rights reserved.
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