Study on the luminescence behavior of sulfobutylether-β-cyclodextrin with risperidone and its analytical application

The interaction of sulfobutylether-beta-cyclodextrin (SBE-beta-CD) with risperidone (RISP) was first described with luminol-SBE-beta-CD chemiluminescence (CL) system by flow injection analysis (FIA). In luminol-SBE-beta-CD CL system, the 1:1 SBE-beta-CD center dot center dot center dot luminor* complexation could enhance CL intensity of luminol and produce the effect of complexation enhancement of CL (CEC). It was found that RISP could quench the CL intensity of SBE-beta-CD center dot center dot center dot luminol* and caused the effect of complexation enhancement of quenching (CEQ), the formation constant KR-CD 3.4 x 10(4) L mol(-1) and the stoichiometric ratio 1:1 of RISP center dot center dot center dot SBE-beta-CD complex were obtained by the proposed CL model. Association degree alpha 0.036 of RISP center dot center dot center dot SBE-beta-CD complex was also given by CL method. Based on the linear relationship to the decrement of luminol-SBE-beta-CD-RISP CL intensity and the logarithm of RISP concentration, RISP also can be quantified in the linear range of 3.0-500.0 nmol L-1 with a detection limit of 1.0 nmol L-1 (3 sigma). The proposed method was successfully applied to monitoring excreted RISP in human urine. It was found that RISP reached its maximum after oral administration for 1.5 h with the total excretion of 14.26% within 8.5 h; the elimination rate constant k and half-life time t(1/2) were 0.474 and 1.5 h, respectively. (C) 2012 Elsevier B.V. All rights reserved.