期刊
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
卷 71, 期 5, 页码 1891-1895出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.saa.2008.07.014
关键词
CA; HP-beta-CD; Fluorescence; H-1 NMR; 2D NMR
类别
资金
- Foundation of Shanxi Province [2006011017]
- High-tech Research and development [2006BA106A20-10]
The inclusion complexation behavior of caffeic acid (CA) with hydroxypropyl-beta-cyclodextrin (HP-beta-CD) was studied by UV-vis, fluorescence spectroscopy and nuclear magnetic resonance spectroscopy (NMR). Experimental conditions including the concentration of HP-beta-CD and media acidity were investigated in detail. The result suggested HP-beta-CD was more suitable for including CA in acidity solution. The binding contants (K) of the inclusion complexes were determined by linear regression analysis and the inclusion ratio was found to be 1:1. The water solubility of CA was increased by inclusion with HP-beta-CD according to the phase-solubility diagram. The spatial configuration of complex has been proposed based on H-1 NMR and two-dimensional (2D) NMR, the result suggested that CA was entrapped inside the hydrophobic core of HP-beta-CD with the lipophilic aromatic ring and the portion of ethylene. (C) 2008 Elsevier B.V. All rights reserved.
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