Synthesis, spectroscopic and thermal characterization of some transition metal complexes of folic acid

Compounds having general formula: [M(FO)(Cl)(x)(H2O)(y)]center dot zH(2)O, where (M = Mn(II), Fe(III), Co(II), Ni(H), Cu(II), Zn(II), Cd(II) and Hg(II), FO = folate anion, x = 2 or 4, y = 2 or 4 and z = 0, 1, 2, 3, 5 or 15) were prepared. The obtained compounds were characterized by elemental analysis, infrared as well as electronic spectra, thermogravimetric analysis and the conductivity measurements. The results suggested that all folate complexes were formed by 2:1 molar ratio (metal:folic acid) as a bidentate through both of the two carboxylic groups. The molar conductance measurements proved that the folate complexes are electrolytes. The kinetic thermodynamic parameters such as: E*, Delta H*, Delta S* and Delta G* were estimated from the DTG curves. The antibacterial evaluation of the folic acid and their complexes was also done against some Gram positive/negative bacteria as well as fungi. (C) 2007 Elsevier B.V. All rights reserved.