期刊
ATHEROSCLEROSIS
卷 239, 期 1, 页码 125-130出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.atherosclerosis.2014.12.046
关键词
Interleukin-5; Atherosclerosis; Cytokines; Coronary artery disease; Intima-media thickness
资金
- European Commission [QLG1-CT-2002-00896]
- Swedish Heart-Lung Foundation
- Swedish Research Council [8691, 0593]
- Knut and Alice Wallenberg Foundation
- Foundation for Strategic Research
- Stockholm County Council [592229]
- Strategic Cardiovascular and Diabetes Programmes of Karolinska Institutet and Stockholm County Council
- European Union [IMI/115006]
- Academy of Finland [110413]
- British Heart Foundation [RG2008/08, RG2008/014]
- Italian Ministry of Health (Ricerca Corrente)
- Karolinska Institutet's research funds
- Magnus Bergvall Foundation
- Foundation for Old Servants
- Academy of Finland (AKA) [110413, 110413] Funding Source: Academy of Finland (AKA)
- British Heart Foundation [RG/08/008/25291] Funding Source: researchfish
Objective: Genetic variants robustly associated with coronary artery disease were reported in the vicinity of the interleukin (IL)-5 locus, and animal studies suggested a protective role for IL-5 in atherosclerosis. Therefore, we set this work to explore IL-5 as a plasma biomarker for early subclinical atherosclerosis, as determined by measures of baseline severity and change over time of carotid intima-media thickness (cIMT). Methods: We used biobank and databases of IMPROVE, a large European prospective cohort study of high-risk individuals (n = 3534) free of clinically overt cardiovascular disease at enrollment, in whom composite and segment-specific measures of cIMT were recorded at baseline and after 15 and 30 months. IL-5 was measured with an immunoassay in plasma samples taken at baseline. Results: IL-5 levels were lower in women than in men, lower in the South than in North of Europe, and showed positive correlations with most established risk factors. IL-5 showed significant inverse relationships with cIMT change over time in the common carotid segment in women, but no significant relationships to baseline cIMT in either men or women. Conclusions: Our results suggest that IL-5 may be part of protective mechanisms operating in early atherosclerosis, at least in women. However, the relationships are weak and whereas IL-5 has been proposed as a potential molecular target to treat allergies, it is difficult to envisage such a scenario in coronary artery disease. (C) 2015 The Authors. Published by Elsevier Ireland Ltd. This is an open access article under the CC BY-NCND license.
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