期刊
SOUTH AFRICAN JOURNAL OF BOTANY
卷 120, 期 -, 页码 286-290出版社
ELSEVIER
DOI: 10.1016/j.sajb.2018.08.023
关键词
Plectranthus scutellarioides; Diterpene glucoside; Flavonoids; Hyaluronidase; ORAC values; Acetylcholinesterase and butyrylcholinesterase; inhibitory activities
资金
- IGA VFU [305/2016/FaF, 303/2017/FaF]
- Ministry of Education, Youth and Sports of the Czech Republic under the activity Projects of major infrastructures for research, development and innovations [LM2011020]
Three new compounds, diterpenoid glucoside (13S, 15S)-6 beta, 7 alpha, 12 alpha-trihydroxy-13 beta, 16-cyclo-8-abietene11,14- dione 7-O-beta-D-glucoside 1, flavonoids apigenin 7-O-(3''-O-acetyl)-beta-D-glucuronide 2 and apigenin 5-O( 3''-O-acetyl)-beta-D-glucuronide 3, together with known compounds caffeic acid 4, luteolin 5-O-beta-D-glucoside 5 and rosmarinic acid 6 were isolated from the aerial parts of Plectranthus scutellarioides (L.) R. Br. The structures of the new compounds were elucidated by spectroscopic and mass-spectrometric analyses, including 1D-and 2D-NMR. Compound 1 inhibited hyaluronidase by 25% at the concentration of 200 mu M, compounds 2 and 3 showed inhibitory activity on butyrylcholinesterase better than standard galanthamine at the concentration of 100 mu M, and compound 6 is a potent antioxidant with an ORAC value of 2.15 +/- 0.12. (c) 2018 SAAB. Published by Elsevier B. V. All rights reserved.
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