期刊
SOUTH AFRICAN JOURNAL OF BOTANY
卷 76, 期 2, 页码 285-288出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.sajb.2009.11.006
关键词
1,2,3,4,6-penta-O-galloyl-beta-D-glucose; Acetylcholinesterase; Butyrylcholinesterase; FRAP assay; Terminalia chebula
资金
- Seo Chun Gun
- National Research Foundation of Korea
- National Research Council of Science & Technology (NST), Republic of Korea [2Z03410] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
- National Research Foundation of Korea [2009-0076459] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
The search for a novel pharmaeotherapy from medicinal plants for neurodegenerative disorders has significantly advanced. Therefore, the present study was performed to evaluate the anticholinesterase activities of one hundred medicinal plants in Korea, where Terminalia chebula (T. chebula) fruits showed significant acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitions. Further bioassay monitored phytochemical exploration led to the isolation of 1,2,3,4,6-penta-O-galloyl-beta-D-glucose (compound 1), which showed significant AChE and BChE inhibitory effects with IC50 values of 29.9 +/- 0.3 mu M and 27.6 +/- 0.2 mu M, respectively. The inhibitory effect of compound 1 towards acetylcholinesterase was also evaluated using TLC and compared with tacrine as the positive control; the positive effect was confirmed. Furthermore, compound 1 also displayed strong antioxidant activity by the FRAP assay (IC50=4.6 +/- 0.2 mu M). In conclusion, compound I may prove to be a potential natural anti-Alzheimer source based on noteworthy AChE and BChE inhibitions, and strong antioxidant activity. (C) 2009 SAAB. Published by Elsevier B.V. All rights reserved.
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