期刊
ADVANCED HEALTHCARE MATERIALS
卷 5, 期 6, 页码 665-675出版社
WILEY
DOI: 10.1002/adhm.201500720
关键词
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资金
- NNSF of China [51472252, 51172244, 11179006, 61227008]
- National Basic Research Program of China (973 Program) [2012CB932400]
- Chinese Academy of Sciences [KGZD-EW-T02]
Cancer nanotheranostics combining therapeutic and imaging functions within a single nanoplatform are extremely important for nanomedicine. In this study, carbon dots (C-dots) with intrinsic theranostic properties are prepared by using polythiophene benzoic acid as carbon source. The obtained C-dots absorb light in the range of 400-700 nm and emit bright fl uorescence in the red region (peaking from 640 to 680 nm at different excitations). More importantly, the obtained C-dots exhibit dual photodynamic and photothermal effects under 635 nm laser irradiation with a singlet oxygen (O-1(2)) generating effi ciency of 27% and high photothermal conversion effi ciency of 36.2%. These unique properties enable C-dots to act as a red-light-triggered theranostic agent for imaging-guided photodynamic-photothermal simultaneous therapy in vitro and in vivo within the therapeutic window (600-1000 nm).
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