期刊
ADVANCED HEALTHCARE MATERIALS
卷 4, 期 10, 页码 1526-1536出版社
WILEY-BLACKWELL
DOI: 10.1002/adhm.201500273
关键词
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资金
- National Natural Science Foundation of China [31170964, U1432114, U1332117, 11475012]
- Chinese Academy of Sciences [2010-735]
- Natural Science Foundation of Zhejiang province [LY15C100002]
- Natural Science Foundation of Ningbo city [2014A610166]
- Carl Zeiss Stiftung (Germany)
White TiO2 nanoparticles (NPs) have been widely used for cancer photodynamic therapy based on their ultraviolet light-triggered properties. To date, biomedical applications using white TiO2 NPs have been limited, since ultraviolet light is a well-known mutagen and shallow penetration. This work is the first report about hydrogenated black TiO2 (H-TiO2) NPs with near infrared absorption explored as photothermal agent for cancer photothermal therapy to circumvent the obstacle of ultraviolet light excitation. Here, it is shown that photothermal effect of H-TiO2 NPs can be attributed to their dramatically enhanced nonradiative recombination. After polyethylene glycol (PEG) coating, H-TiO2-PEG NPs exhibit high photothermal conversion efficiency of 40.8%, and stable size distribution in serum solution. The toxicity and cancer therapy effect of H-TiO2-PEG NPs are relative systemically evaluated in vitro and in vivo. The findings herein demonstrate that infrared-irradiated H-TiO2-PEG NPs exhibit low toxicity, high efficiency as a photothermal agent for cancer therapy, and are promising for further biomedical applications.
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