期刊
SOFT MATTER
卷 10, 期 9, 页码 1356-1364出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c3sm52518j
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资金
- NSF [2736B48, 0965945]
- Georgia Tech Center for Drug Design, Development and Delivery
- Japan Society for the Promotion of Science (JSPS)
- NIH [1 R01 GM088291-01, R01 AR062920]
- training grant: GTBioMAT Graduate Training for Rationally Designed, Integrative Biomaterials [T32 EB 006343]
- U.S. DOE GAANN award
- Georgia Tech TI: GER program
- NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES [R01AR062920] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING [T32EB006343] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM088291] Funding Source: NIH RePORTER
A material's mechanical properties greatly control cell behavior at the cell-substrate interface. In this work, we demonstrate that microgel multilayers have unique elastic and viscoelastic-like properties that can be modulated to produce morphological changes in fibroblasts cultured on the film. Protein adsorption is also examined and the data are contrasted with the number of cells adhered. The dynamic interaction of cell and substrate is only partially explained by conventional understanding of surface-receptor interactions and substrate elasticity. Viscoelasticity, a mechanical property not often considered, plays a significant role at cellular length and time scales for microgel films.
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