期刊
ADVANCED HEALTHCARE MATERIALS
卷 4, 期 16, 页码 2488-2499出版社
WILEY
DOI: 10.1002/adhm.201500004
关键词
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资金
- EU [251385, 263289]
- Science Foundation Ireland [SFI_09-RFP-ENM2483, 11/SIRG/B2135.9]
- Health Research Board, Health Research Awards Programme [HRA_POR/2011/84]
- Enterprise Partnership Scheme, Irish Research Council [EPSPG/2011/64]
- Enterprise Ireland, Collaborative Centre for Applied Nanotechnology under the Irish Government [CCIRP-2007-CCAN-0509]
- Tyndall National Institute, SFI [NAP382]
- New Foundations, Irish Research Council
Cells within a tissue are able to perceive, interpret and respond to the biophysical, biomechanical, and biochemical properties of the 3D extracellular matrix environment in which they reside. Such stimuli regulate cell adhesion, metabolic state, proliferation, migration, fate and lineage commitment, and ultimately, tissue morphogenesis and function. Current scaffold fabrication strategies in musculoskeletal tissue engineering seek to mimic the sophistication and comprehensiveness of nature to develop hierarchically assembled 3D implantable devices of different geometric dimensions (nano-to macrometric scales) that will offer control over cellular functions and ultimately achieve functional regeneration. Herein, advances and shortfalls of bottom-up (self-assembly, freeze-drying, rapid prototype, electrospinning) and top-down (imprinting) scaffold fabrication approaches, specific to musculoskeletal tissue engineering, are discussed and critically assessed.
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