期刊
SOFT MATTER
卷 9, 期 12, 页码 3389-3395出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c3sm27559k
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资金
- IUPAC Transnational Call in Polymer Chemistry
- NSF [MSN 1057970, DMR 0907453]
- Department of Defense Prostate Cancer Research Program [W81XWH-09-1-0584]
- Direct For Mathematical & Physical Scien [0907453, 1057970] Funding Source: National Science Foundation
- Division Of Chemistry [1057970] Funding Source: National Science Foundation
- Division Of Materials Research [0907453] Funding Source: National Science Foundation
We describe the preparation and assembly of glycosylated amphiphilic diblock copolypeptides, where the hydrophilic glycosylated segments adopt either alpha-helical or disordered conformations. In this study, glycosylated amphiphilic diblock copolypeptides were prepared using poly(L-leucine), poly(L), as the hydrophobic segment, and poly(alpha-D-galactopyranosyl-L-lysine), poly(alpha-gal-K), or poly(alpha-D-galactopyranosyl-L-cysteine sulfone), poly(alpha-gal-C-O2), as the hydrophilic segment. The poly(alpha-gal-K) and poly(alpha-gal-C-O2) segments are known to be fully alpha-helical (>90% at 20 degrees C) and fully disordered in water, respectively. We found that block copolypeptides containing galactosylated hydrophilic segments of either alpha-helical or disordered conformation give different assembly morphologies, where the disordered glycopolypeptide segments favor vesicle formation and also present sugar residues that can bind to biological targets.
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