期刊
SOFT MATTER
卷 8, 期 34, 页码 8811-8821出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c2sm25721a
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资金
- Natural Science Foundation of China [50830106, 21174126]
- China National Funds for Distinguished Young Scientists [51025312]
- National Basic Research Program of China [2011CB606203]
- Foundation of Ministry of Education of China [20110101110037]
- State Key Laboratory of Supramolecular Structure and Materials [SKLSSM 201204]
Biocompatible and biodegradable polymersomes are commonly self-assembled from amphiphilic diblock copolymers composed of hydrophilic poly(ethylene glycol) (PEG) or poly-(2-methacryloyloxyethyl phosphorylcholine) (PMPC) segments and hydrophobic polyester blocks, such as poly(lactic acid) (PLA) or poly(epsilon-caprolactone) (PCL). Such polymersomes have emerged as promising delivery vehicles for pharmaceutical applications. Presented in this review are summaries of recent developments of biocompatible and biodegradable polymersomes, including self-assembly, encapsulation of various therapeutics, pH-induced hydrolysis for controlled release as well as their functionalization and intelligent design.
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