4.6 Article

Encoding cell-instructive cues to PEG-based hydrogels via triple helical peptide assembly

期刊

SOFT MATTER
卷 8, 期 40, 页码 10409-10418

出版社

ROYAL SOC CHEMISTRY
DOI: 10.1039/c2sm25903f

关键词

-

资金

  1. NSF [DMR-0645411]
  2. NIAMS/NIH [R01AR060484]
  3. DOD
  4. HHMI Graduate Training Program (NBMed)
  5. National Defense Science and Engineering Graduate Fellowship Program [32 CFR 168a]

向作者/读者索取更多资源

Effective synthetic tissue engineering scaffolds mimic the structure and composition of the natural extracellular matrix (ECM) to promote optimal cellular adhesion, proliferation, and differentiation. Among many proteins of the ECM, collagen and fibronectin are known to play a key role in the structural integrity of the scaffold as well as its ability to support cell adhesion. Here, we present photocrosslinked poly(ethylene glycol) diacrylate (PEGDA) hydrogels displaying collagen mimetic peptides (CMPs) that can be further conjugated to bioactive molecules via a CMP-CMP triple helix association. Pre-formed PEGDA-CMP hydrogels can be encoded with varying concentrations of cell-signaling CMP-RGD peptides similar to cell adhesive fibronectin decorating the collagen fibrous network by non-covalent binding. Furthermore, the triple helix mediated encoding allows facile generation of spatial gradients and patterns of cell-instructive cues across the cell scaffold that simulate the distribution of insoluble factors in the natural ECM.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.6
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据