期刊
SOFT MATTER
卷 8, 期 7, 页码 2095-2102出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c1sm05706e
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资金
- NSERC (Canada)
- APCTP
- NRF of Korea [2009-008769]
- MEST
- Harvard University, USA
- US National Institutes of Health [P50 GM068763]
Chromosomes in living cells are strongly confined but show a high level of spatial organization. Similarly, confined polymers display intriguing organizational and segregational properties. Here, we discuss how ring topology influences self-avoiding polymers confined in a cylindrical space, i.e. individual polymers as well as the way they interact. Our molecular dynamics simulations suggest that a ring polymer can be viewed as a parallel connection'' of two linear subchains, each trapped in a narrower imaginary tube. As a consequence, ring topology stiffens'' individual chains about fivefold and enhances their segregation appreciably, as if it induces extra linear ordering. Using a renormalized'' Flory approach, we show how ring topology influences individual chains in the long chain limit. Our polymer model quantitatively explains the long-standing observations of chromosome organization and segregation in E. coli.
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