期刊
SOFT MATTER
卷 8, 期 13, 页码 3665-3672出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c2sm25060h
关键词
-
类别
资金
- National Natural Science Foundation of China [21074152, 21104099, 20874116]
- Education Ministry in China [20090171110023]
- Key Project of Scientific and Technical Innovation for Universities in Guangdong Province, China [cxzd1102]
Novel supramolecular hydrogel/micelle composites were designed for the co-encapsulation and prolonged release of camptothecin (CPT) and granulocyte colony-stimulating factor (G-CSF). For this purpose, heparin-conjugated Pluronic F-127 (Hep-F-127) was synthesized by a click reaction and then used to self-assemble the micelles with their hydrophobic cores loaded with CPT and hydrophilic shells complexed with G-CSF. By mixing alpha-cyclodextrin (alpha-CD) and CPT-loaded Hep-F-127 micelle/G-CSF complexes in an aqueous system, the supramolecular hydrogel/micelle composite with good injectability could be formed under mild conditions. For the co-encapsulated CPT and G-CSF, they could maintain their biological activity and exhibit a more prolonged release when compared to CPT-loaded Hep-F-127 micelles/G-CSF complexes. Moreover, the gelation properties and drug release profiles could by tuned by alpha-CD amount.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据