期刊
SOFT MATTER
卷 7, 期 19, 页码 8762-8765出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c1sm06026k
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资金
- NSF [DMR-1006546]
- Harvard MRSEC [DMR-0820484]
- University of Hong Kong [201101159009]
- BASF
We introduce an approach that combines the concepts of emulsion-templating and dewetting for fabricating polymersomes with a large number of compartments. The resultant polymersome gel behaves as a gel-like solid, but is a true vesicle suspended in an aqueous environment. Due to the thin membranes that separate the compartments, the polymersome gels have a high volume fraction of internal phase for encapsulation of hydrophilic actives; they also provide a large surface area of diblock copolymer membrane for encapsulation of lipophilic actives. Multiple actives can also be encapsulated in the gel without cross-contamination. Our technique represents a simple and versatile bulk approach for fabricating polymersome gels; it does not require the use of any specialized equipment or subsequent polymerization steps to solidify the gel. The resultant polymersome gel is promising as an encapsulating structure as well as a scaffold for tissue engineering.
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