期刊
ACS MACRO LETTERS
卷 4, 期 9, 页码 996-999出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsmacrolett.5b00525
关键词
-
资金
- National Basic Research Program [2013CB834502]
- NSFC/China [91027006, 21125417, 21434005]
- Key Science Technology Innovation Team of Zhejiang Province [2013TD02]
Here we report a redox-responsive host-guest complex between a new water-soluble pillar[5]arene (WP5) and a paraquat derivative. Compared with the neutral form of the paraquat derivative that binds WP5 weakly, its dication form binds WP5 much more strongly. Furthermore, we utilize this new water-soluble redox-responsive molecular recognition motif to construct the first pillararene-based amphiphilic macromolecular [2]-pseudorotaxane, which self-assembles into redox-responsive polymeric vesicles in water. Such pillararene-based supramolecular vesicles were further used to construct a drug delivery system to encapsulate and controlled release DOX center dot HCl, an anticancer drug. The uptake of these DOX center dot HCl-loaded supramolecular vesicles by cancer cells was studied with confocal laser scanning microscopy. Meanwhile, DOX center dot HCl-loaded supramolecular vesicles showed anticancer activity in vitro comparable to free DOX center dot HCl under the examined conditions.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据