期刊
SOFT MATTER
卷 6, 期 19, 页码 4847-4850出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c0sm00345j
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资金
- EU [FP6-2004-NMP-NI-4/IP 026668-2]
Block copolymer vesicles containing paramagnetic lanthanide complexes represent a versatile class of MRI contrast agents. By exploiting the water flux across the membrane, these nanovesicles can be employed as T-1- and CEST MRI contrast agents. The incorporation of paramagnetic amphiphilic lipids (Gd-1 for T-1 MRI CAs agents and Tm-2 for CEST MRI CAs) into the polymeric bilayer markedly improves the properties of the MRI contrast agents with respect to the longitudinal relaxivity (22 mM(-1) s(-1) at 20 MHz) and the chemical shift of the intrapolymersomal water protons.
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