期刊
SOFT MATTER
卷 5, 期 7, 页码 1530-1538出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/b819396g
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资金
- Chinese Academy of Sciences (CAS)
- National Natural Scientific Foundation of China (NNSFC) [20534020, 20874092, 20674079, 50425310]
- Specialized Research Fund for the Doctoral Program of Higher Education (SRFDP)
- Changjiang Scholars and Innovative Research Team in University (PCSIRT)
- Natural Sciences and Engineering Research Council of Canada
Alkynyl-terminated double hydrophilic ABC triblock copolymer, poly(oligo(ethylene glycol) monomethyl ether methacrylate)-b-poly(2-(dimethylamino) ethyl methacrylate)-b-poly(2-diethylamino) ethyl methacrylate) (alkynyl-POEGMA-b-PDMA-b-PDEA), was synthesized via atom transfer radical polymerization (ATRP) by sequential monomer addition using propargyl 2-bromoisobutyrate (PgBiB) as the initiator. The obtained triblock copolymer dissolves molecularly in acidic media and self-assembles into alkynyl surface-functionalized three-layer onion-like'' micelles consisting of a PDEA core, a PDMA inner shell, and a POEGMA corona at alkaline pH. Selective cross-linking of the PDMA inner shell with 2-bis(2-iodoethoxy)ethane(BIEE) results in structurally stable and surface 'clickable' shell cross-linked (SCL) micelles with pH-responsive PDEA cores. This new kind of SCL micelles could be further surface functionalized or conjugated with other azido-terminated polymer chains, functional groups, or biomolecules via Click chemistry. Four layer nanoparticles (SCL-PNIPAM) which have pH-responsive PDEA cores and temperature responsive PNIPAM outer coronas were fabricated from surface 'clickable' shell cross-linked (SCL) micelles and azide-terminated poly(N-isopropylacrylamide) (PNIPAM-N-3) using Click chemistry. These novel four layer nanoparticles might act as suitable nano-sized drug delivery vehicles for the encapsulation and release of hydrophobic drugs as a function of either temperature or pH of the environment
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