期刊
SOFT MATTER
卷 4, 期 12, 页码 2310-2315出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/b805563g
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资金
- National Science Foundation [CHE-0802286]
- National Institutes of Health (NIDCR) [DE017703]
- NIBIB [EB007335]
- American Heart Association [0665218B]
- NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING [R21EB007335] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF DENTAL &CRANIOFACIAL RESEARCH [R21DE017703] Funding Source: NIH RePORTER
Self-assembling biomaterials are promising as cell-interactive matrices because they can be constructed in a modular fashion, which enables the independent and simultaneous tuning of several of their physicochemical and biological properties. Such modularity facilitates the optimization of multi-component matrices for use in complex biological environments such as 3-D cell culture or scaffolds for regenerative medicine. This Highlight will discuss recent strategies for producing modular self-assembling biomaterials, with a particular focus on how ligand presentation and matrix mechanics can be controlled in modular ways. In addition, it will discuss key hurdles that remain for employing these materials as cell-interactive scaffolds in biomedical applications, particularly those challenges that relate to how they may interface with the immune system.
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