Polymersomes from Amphiphilic Glycopolymers Containing Polymeric Liquid Crystal Grafts

For the first time, polymersomes were obtained by self-assembly in water of ampliiphilic grafted glycopolymers based on dextran polysaccharidic backbone and polymeric liquid crystal grafts (poly(diethylene glycol cholesteryl ether acrylate), PDEGCholA). After measuring the properties of these glycopolymers in term of surfactancy, the influence of their structural parameters on their self-assemblies once dispersed in water was investigated by static and dynamic light scattering and by cryogenic transmission electron microscopy (cryo-TEM). Based on the results, a proper design of Dex-g(N)-PDEGCholA(F) leads to hollow vesicular structure formulation known as polymersome.