4.2 Article

Synthesis and Characterization of Antimicrobial Polyvinyl Pyrrolidone Hydrogel as Wound Dressing

期刊

SOFT MATERIALS
卷 12, 期 3, 页码 297-305

出版社

TAYLOR & FRANCIS INC
DOI: 10.1080/1539445X.2013.831357

关键词

Antimicrobial activity; Guanidine oligomer; Hydrogels; Wound dressing

资金

  1. Shanghai Natural Science Foundation [12ZR1407800]
  2. Shanghai Leading Academic Discipline Project [B502]
  3. Shanghai Key Laboratory Project [08DZ2230500]

向作者/读者索取更多资源

Novel antimicrobial PVP-GP hydrogels were prepared by polycondensation of hexamethylenediamine and guanidine hydrochloride, followed by cross-linking reaction using N-vinyl pyrrolidone (NVP) and N,N'-methylene bisacrylamide (MBAm). The products were characterized by H-1 NMR, FTIR, SEM, and their performances for wound dressing applications were also evaluated. Swelling study showed that the water absorptivity of the hydrogels decreased as the cross-linking density increased either in water or in physiological saline solution. Both PVP and PVP-GP hydrogels possessed excellent mechanical strength which could address the requirements for wound dressing. The water vapor transmission rates (WVTR) of PVP and PVP-GP hydrogels were in the range of 1727-2320 g/m(2)/day, indicating that the prepared hydrogels were suitable for wound dressings without dehydrating the wound surface or accumulating exudates. Kirby-Bauer inhibition zone test and microbe penetration assay proved that the PVP-GP hydrogels had high antimicrobial activity.

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