期刊
SOFT MATERIALS
卷 11, 期 3, 页码 244-253出版社
TAYLOR & FRANCIS INC
DOI: 10.1080/1539445X.2011.622030
关键词
Cornea; Glaucoma; Nanoindentation
资金
- Research Grants Council [HKU 716908E]
- University Grants Committee of the Hong Kong Special Administration Region, P.R. China [SEG-HKU06]
- Croucher Foundation
Elevated intraocular pressure (IOP) is the main risk factor of glaucoma. In this study, an elevated IOP was introduced into the right eye balls of Sprague-Dawley rats, while their left eye balls were kept at a normal state. Nanoindentation showed that the elastic modulus of normal corneas was 2.75-3.33 MPa, whereas that of elevated IOP group was higher at 4.89-5.58 MPa. Scanning electron microscopy imaging suggested that the collagen fibrils subjected to the elevated IOP became thinner and with random directionality. It is believed the observed increase in elastic modulus should due to the strain-stiffening effects of collagen fibrils.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据