期刊
SOCIAL NEUROSCIENCE
卷 6, 期 5-6, 页码 436-451出版社
ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
DOI: 10.1080/17470919.2011.586880
关键词
Perceptual expertise; N170; Event-related potential (ERP/EEG); Face perception; Autism spectrum disorder
资金
- NIMH [R03 MH079908, K23 MH086785]
- NICHD [PO1HD003008]
- NARSAD
- CTSA from National Center for Research Resources (NCRR), a component of the National Institutes of Health (NIH) [UL1 RR024139]
- NIH Roadmap for Medical Research (USA)
- EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH &HUMAN DEVELOPMENT [P01HD003008] Funding Source: NIH RePORTER
- NATIONAL CENTER FOR RESEARCH RESOURCES [UL1RR024139] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF MENTAL HEALTH [R03MH079908, K23MH086785] Funding Source: NIH RePORTER
The social motivation hypothesis posits that aberrant neural response to human faces in autism is attributable to atypical social development and consequently reduced exposure to faces. The specificity of deficits in neural specialization remains unclear, and alternative theories suggest generalized processing difficulties. The current study contrasted neural specialization for social information versus nonsocial information in 36 individuals with autism and 18 typically developing individuals matched for age, race, sex, handedness, and cognitive ability. Event-related potentials elicited by faces, inverted faces, houses, letters, and pseudoletters were recorded. Groups were compared on an electrophysiological marker of neural specialization (N170), as well as behavioral performance on standardized measures of face recognition and word reading/decoding. Consistent with prior results, individuals with autism displayed slowed face processing and decreased sensitivity to face inversion; however, they showed comparable brain responses to letters, which were associated with behavioral performance in both groups. Results suggest that individuals with autism display atypical neural specialization for social information but intact specialization for nonsocial information. Findings concord with the notion of specific dysfunction in social brain systems rather than nonspecific information-processing difficulties in autism.
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