期刊
SOCIAL COGNITIVE AND AFFECTIVE NEUROSCIENCE
卷 8, 期 6, 页码 609-616出版社
OXFORD UNIV PRESS
DOI: 10.1093/scan/nss038
关键词
periaqueductal gray; emotion; affect; pain; fMRI
资金
- National Institute of Mental Health [NIH MH076137, NIH MH076136, NIH RC1DA028608, NIH R01DA027794]
- National Institute of Drug Addiction [NIDA DA022541, NSF 0631637]
- Mind and Life Institute, through a 2005 Mind and Life Summer Research Institute
Human neuroimaging offers a powerful way to connect animal and human research on emotion, with profound implications for psychological science. However, the gulf between animal and human studies remains a formidable obstacle: human studies typically focus on the cortex and a few subcortical regions such as the amygdala, whereas deeper structures such as the brainstem periaqueductal gray (PAG) play a key role in animal models. Here, we directly assessed the role of PAG in human affect by interleaving in a single fMRI session two conditions known to elicit strong emotional responses-physical pain and negative image viewing. Negative affect and PAG activity increased in both conditions. We next examined eight independent data sets, half featuring pain stimulation and half negative image viewing. In sum, these data sets comprised 198 additional participants. We found increased activity in PAG in all eight studies. Taken together, these findings suggest PAG is a key component of human affective responses.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据