期刊
SOCIAL COGNITIVE AND AFFECTIVE NEUROSCIENCE
卷 4, 期 4, 页码 357-368出版社
OXFORD UNIV PRESS
DOI: 10.1093/scan/nsp025
关键词
serotonin; emotional memory; negative attentional bias; distraction; fMRI
资金
- Duke Silvio O. Conte Center for the Neuroscience of Depression [P50-MH60451]
- Paul B. Beeson Career Developmental Awards [K23-AG028982]
- NATIONAL INSTITUTE OF MENTAL HEALTH [P50MH060451] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON AGING [K23AG028982] Funding Source: NIH RePORTER
Serotonin is a key neurotransmitter involved in emotional regulation and memory. A number of studies using acute tryptophan depletion (ATD) in healthy subjects have shown that a temporary serotonin reduction both induces a negative emotional bias and impairs long-term memory. However, little is known about the specific effects of ATD on emotional memory. Using functional magnetic resonance imaging (fMRI), we investigated the effect of ATD on negative memory and executive function in healthy volunteers. Our emotional oddball task required participants to distinguish infrequently presented targets from distracting negative and neutral pictures. Memory for the distracting pictures was tested 1 h following the fMRI session. ATD selectively enhanced memory for negative distractors relative to neutral distractors and increased activation in response to the negative distractors in the left orbital-inferior frontal, dorsomedial prefrontal and bilateral angular gyri. ATD also induced greater activation in the left inferior frontal gyrus and anterior cingulate across all stimuli. Stronger frontal activation to distractors was positively correlated with memory performance on ATD but not control days, indicating a possible compensatory mechanism for coping with increased task demand under the ATD challenge. These findings highlight the importance of serotonin in negative memory with implications for mood disorders.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据