期刊
SOCIAL COGNITIVE AND AFFECTIVE NEUROSCIENCE
卷 3, 期 3, 页码 290-297出版社
OXFORD UNIV PRESS
DOI: 10.1093/scan/nsn029
关键词
functional magnetic resonance imaging; group studies; aging; hemodynamics; spatial normalization; ROI
资金
- National Institute of Mental Health [5T32-MH019956]
- National Institute on Aging [5R01-AG015793]
- National Institute of Neurological Disorders and Stroke [2P01-NS040813]
With the recent growth of functional magnetic resonance imaging (fMRI), scientists across a range of disciplines are comparing neural activity between groups of interest, such as healthy controls and clinical patients, children and young adults and younger and older adults. In this edition of Tools of the Trade, we will discuss why great caution must be taken when making group comparisons in studies using fMRI. Although many methodological contributions have been made in recent years, the suggestions for overcoming common issues are too often overlooked. This review focuses primarily on neuroimaging studies of healthy aging, but many of the issues raised apply to other group designs as well.
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