期刊
VIRULENCE
卷 6, 期 3, 页码 244-248出版社
TAYLOR & FRANCIS INC
DOI: 10.1080/21505594.2014.999570
关键词
Head and neck cancer; Human papillomavirus; oral squamous cell cancer
资金
- Jean-Uhrmacher Foundation
Increased awareness of human papillomavirus (HPV) as an etiological cause of head and neck squamous cell carcinoma has increased the interest in analysis of distinct oral sub-sites. It is currently under debate, whether HPV plays a role in the development of squamous cell carcinoma of the oral cavity (OSCC). The weakness in most published studies is the lack of performing different HPV detection tests combined with analysis for biological activity of the virus. In addition, different sub-sites of the oral cavity had been combined to a single entity, which retrospectively leads to a highly heterogeneous basis of data. In this review we mainly discuss the unclear role of HPV in OSCC development.
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