期刊
SMALL RUMINANT RESEARCH
卷 112, 期 1-3, 页码 191-198出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.smallrumres.2012.11.028
关键词
Allergic sensitization; Hypersensitivity; Milk proteins; Humoral response; Lymphocyte proliferation index; Cow; Buffalo and goat
资金
- National Dairy Research Institute (ICAR), Karnal
Milk hypersensitivity due to adverse reactions to milk proteins is among the major public concern of food allergies. In present investigation, comparative assessment of humoral and cell mediated immune responses in mice associated with allergenicity of major milk proteins (casein and beta-lactoglobulin) of cow, buffalo and goat were carried out. Caseins of all three species of dairy animals appeared to be less immunogenic and allergenic than their corresponding beta-lactoglobulins. Cow milk proteins (caseins and beta-lactoglobulin) were observed to increase protein specific IgE sensitization as well as lymphocyte proliferation index significantly (P < 0.01) as compared to buffalo and goat milk proteins. On the other hand, buffalo and goat milk proteins similar to cow's proteins raised remarkably higher (P < 0.01) immunogenic response in terms of IgG levels than the negative control group. The results obtained were correlated with B and T cell epitopes of milk proteins cited in literature after multiple alignment in silico. Thus present study suggests cow milk proteins (beta-lactoglobulin and casein) are highly allergenic among the milk proteins of three species of dairy animals. (C) 2012 Elsevier B.V. All rights reserved.
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