期刊
SMALL
卷 10, 期 9, 页码 1687-1703出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/smll.201302907
关键词
microfluidics; lab-on-a-chip; blood; cell separation; sample preparation
类别
资金
- National Science Foundation [CMMI 1129611, CBET 1149401, ECCS 1231826, CBET 1263889]
- National Institute of Health [1R21HL114011]
- American Heart Association [12SDG12180025]
- Department of Mechanical Engineering at the University of Michigan, Ann Arbor
- Directorate For Engineering [1231826] Funding Source: National Science Foundation
- Div Of Electrical, Commun & Cyber Sys [1231826] Funding Source: National Science Foundation
Blood plays an important role in homeostatic regulation with each of its cellular components having important therapeutic and diagnostic uses. Therefore, separation and sorting of blood cells hasa been of a great interest to clinicians and researchers. However, while conventional methods of processing blood have been successful in generating relatively pure fractions, they are time consuming, labor intensive, and are not optimal for processing small volume blood samples. In recent years, microfluidics has garnered great interest from clinicians and researchers as a powerful technology for separating blood into different cell fractions. As microfluidics involves fluid manipulation at the microscale level, it has the potential for achieving high-resolution separation and sorting of blood cells down to a single-cell level, with an added benefit of integrating physical and biological methods for blood cell separation and analysis on the same single chip platform. This paper will first review the conventional methods of processing and sorting blood cells, followed by a discussion on how microfluidics is emerging as an efficient tool to rapidly change the field of blood cell sorting for blood-based therapeutic and diagnostic applications.
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