期刊
SMALL
卷 10, 期 18, 页码 3735-3741出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/smll.201400215
关键词
cancer cells; hierarchical structures; structure-property relationships; bioinspired materials; specific recognition
类别
资金
- National Research Fund for Fundamental Key Projects [2012CB933800, 2013CB933000, 2012CB934100]
- National Natural Science Foundation [21121001, 21127025, 21175140, 20974113]
- Chinese Academy of Sciences [KJZD-EW-M01]
- National High Technology Research and Development Program of China (863 Program) [2013AA031903]
By mimicking certain biochemical and physical attributes of biological cells, bio-inspired particles have attracted great attention for potential biomedical applications based on cell-like biological functions. Inspired by leukocytes, hierarchical biointerfaces are designed and prepared based on specific molecules-modified leukocyte-inspired particles. These biointerfaces can efficiently recognize cancer cells from whole blood samples through the synergistic effect of molecular recognition and topographical interaction. Compared to flat, mono-micro or nano-biointerfaces, these micro/nano hierarchical biointerfaces are better able to promote specific recognition interactions, resulting in an enhanced cell-capture efficiency. It is anticipated that this study may provide promising guidance to develop new bio-inspired hierarchical biointerfaces for biomedical applications.
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