期刊
SMALL
卷 10, 期 22, 页码 4487-4504出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/smll.201401532
关键词
intracellular delivery; targeted delivery; cell receptors; nanoneedle arrays
类别
资金
- City University of Hong Kong [9667053, 9667068]
- National Natural Science Foundation of China [51272217]
The majority of drugs and biomolecules need to be delivered into cells to be effective. However, the cell membranes, a biological barrier, strictly resist drugs or biomolecules entering cells, resulting in significantly reduced intracellular delivery efficiency. To overcome this barrier, a variety of intracellular delivery approaches including chemical and physical ways have been developed in recent years. In this review, the focus is on summarizing the nanomaterial routes involved in making use of a collection of receptors for the targeted delivery of drugs and biomolecules and the physical ways of applying micro- and nanotechnologies for high-throughput intracellular delivery.
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