期刊
SMALL
卷 10, 期 1, 页码 169-178出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/smll.201301283
关键词
antibacterial silver release; plasmonic heating; melanin-mimetic polydopamine; antibodies; metal nanorods
类别
资金
- Ruth Kirschstein National Research Service Award (NRSA) from the National Institute of Dental and Craniofacial Research [NIH F31 DE019750]
- National Science Foundation [NSF GRFP 2011124091]
- Ryan Fellowship (Northwestern University)
- NIH [R37 DE014193, R01 CA128641, R01 EB003682]
- NSF [CBET-0937987]
- [RO1 EB005772]
Illumination of noble metal nanoparticles at the plasmon resonance causes substantial heat generation, and the transient and highly localized temperature increases that result from this energy conversion can be exploited for photothermal therapy by plasmonically heating gold nanorods (NRs) bound to cell surfaces. Here, plasmonic heating is used for the first time to locally release silver from gold core/silver shell (Au@Ag) NRs targeted to bacterial cell walls. A novel biomimetic method of preparing Au@Ag core-shell NRs is employed, involving deposition of a thin organic polydopamine (PD) primer onto Au NR surfaces, followed by spontaneous electroless silver metallization, and conjugation of antibacterial antibodies and passivating polymers for targeting to gram-negative and gram-positive bacteria. Dramatic cytotoxicity of S. epidermidis and E. coli cells targeted with Au@Ag NRs is observed upon exposure to light as a result of the combined antibacterial effects of plasmonic heating and silver release. The antibacterial effect is much greater than with either plasmonic heating or silver alone, implying a strong therapeutic synergy between cell-targeted plasmonic heating and the associated silver release upon irradiation. The findings suggest a potential antibacterial use of Au@Ag NRs when coupled with light irradiation, which has not been previously described.
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