期刊
SMALL
卷 9, 期 18, 页码 3093-3102出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/smll.201300171
关键词
conjugated polymers; FR; NIR emission; fluorescent probes; in vivo fluorescence imaging; in vivo toxicity
类别
资金
- Singapore National Research Foundation [R-279-000-390-281]
- Temasek Defence Systems Institute of Singapore [R279-000-305-592/422/232]
- Singapore-MIT Alliance for Research and Technology (SMART) Innovation Grant [R279-000-378-592]
- Institute of Materials Research and Engineering of Singapore [IMRE/11-1C0213]
- National Science Foundation of China [20974028, 21074051]
A highly emissive far-red/near-infrared (FR/NIR) fluorescent conjugated polymer (CP), poly[(9,9-dihexylfluorene)-co-2,1,3-benzothiadiazole-co-4,7-di(thiophen-2-yl)-2,1,3-benzothiadiazole] (PFBTDBT10) is designed and synthesized via Suzuki polymerization. Formulation of PFBTDBT10 using 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-2000] (DSPE-PEG(2000)) and DSPE-PEG(5000)-folate as the encapsulation matrix yielded CP-loaded DSPE-PEG-folic acid nanoparticles (CPDP-FA NPs) with bright FR/NIR fluorescence (27% quantum yield) and a large Stoke's shift of 233 nm in aqueous solution. CPDP-FA NPs show improved thermal/photostabilities and larger Stoke's shifts as compared to commercially available quantum dots (Qdot 655) and organic dyes such as Alexa Fluor 555 and Rhodamine 6G. In vivo studies of CPDP-FA NPs on a hepatoma H22 tumor-bearing mouse model reveal that they could serve as an efficient FR/NIR fluorescent probe for targeted in vivo fluorescence imaging and cancer detection in a high contrast and specific manner. Together with the negligible in vivo toxicity, CPDP-FA NPs are promising FR/NIR fluorescent probes for future in vivo applications.
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