期刊
SMALL
卷 9, 期 16, 页码 2793-2800出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/smll.201201916
关键词
photodynamic therapy; DNA; drug delivery; mesoporous materials; nanoparticles
类别
资金
- National Basic Research Program of China [2012CB720602, 2011CB936004]
- National Natural Science Foundation of China [20831003, 21210002, 91213302, 20833006, 21072182, 90913007]
A novel light-operated vehicle for targeted intracellular drug delivery is constructed using photosensitizer-incorporated G-quadruplex DNA-capped mesoporous silica nanoparticles. Upon light irradiation, the photosensitizer generates ROS, causing the DNA capping to be cleaved and allowing cargo to be released. Importantly, this platform makes it possible to develop a drug-carrier system for the synergistic combination of chemotherapy and PDT for cancer treatment with spatial/temporal control. Furthermore, the introducing of targeting ligands further improves tumor targeting efficiency. The excellent biocompatibility, cell-specific intracellular drug delivery, and cellular uptake properties set up the basis for future biomedical application that require in vivo controlled, targeted drug delivery.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据