期刊
SMALL
卷 8, 期 11, 页码 1752-1761出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/smll.201200028
关键词
cancer therapy; drug delivery; mesoporous materials; nanoparticles; RNA interference
类别
资金
- National Research Foundation of Korea (NRF)
- Korean government (MEST) [313-2008-2-C00538, 2008-0062074, 2010-0000602, 2011-0017356, 2011-0020322]
- NRF
- MEST in Korea [2008-2004457, 20100029665, R31-2010-000-10071-0]
- Korean Government (MEST)
- National Research Foundation of Korea [CG038302, 2008-2004457, R31-2010-000-10071-0, 2008-0059125, 2008-0062074, 과06A1501, 2011-0017356, 313-2008-2-C00538, CG035001] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Among various nanoparticles, mesoporous silica nanoparticles (MSNs) have attracted extensive attention for developing efficient drug-delivery systems, mostly due to their high porosity and biocompatibility. However, due to the small pore size, generally below 5 nm in diameter, potential drugs that are loaded into the pore have been limited to small molecules. Herein, a small interfering RNA (siRNA) delivery strategy based on MSNs possessing pores with an average diameter of 23 nm is presented. The siRNA is regarded as a powerful gene therapeutic agent for treatment of a wide range of diseases by enabling post-transcriptional gene silencing, so-called RNA interference. Highly efficient, sequence-specific, and technically very simple target gene knockdown is demonstrated using MSNs with ultralarge pores of size 23 nm in vitro and in vivo without notable cytotoxicity.
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