期刊
SMALL
卷 8, 期 12, 页码 1895-1903出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/smll.201102255
关键词
gold nanoparticles; intracellular oxidative stress; peroxidase activity; ceria; nanomedicine
类别
资金
- Spanish ministry of Science [CTQ2006-06785, CTQ2007-67805-AR07, PI10/1195, AP192/11]
- Spanish Ministry of Education
- Regional Ministry of Health of the Valencian Community
- Carlos III Health Institute [ACOMP/2012/045, CES10/030]
- VALi+D contract [APOSTD/2011/049]
Ceria-supported gold nanoparticles are prepared exhibiting peroxidase activity and acting as radical traps. Au/CeO2 shows a remarkable biocompatibility as demonstrated by measuring cellular viability, proliferation, and lack of apoptosis for two human cell lines (Hep3B and HeLa). The antioxidant activity of Au/CeO2 against reactive oxygen species (ROS) is demonstrated by studying the cellular behavior of Hep3B and HeLa in a model of cellular oxidative stress. It is determined that Au/CeO2 exhibits higher antioxidant activity than glutathione, the main cytosolic antioxidant compound, and its CeO2 carrier. Overall the result presented here shows the potential of implementing well-established nanoparticulated gold catalysts with remarkable biocompatibility in cellular biology.
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