期刊
SMALL
卷 9, 期 9-10, 页码 1533-1545出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/smll.201201531
关键词
iron oxide nanoparticles; magnetic resonance imaging; drug delivery; gene delivery; nanotoxicity
类别
资金
- Major State Basic Research Development Program of China (973 Program) [2013CB733802]
- National Science Foundation of China (NSFC) [81101101, 51273165, 51173117, 50830107]
- Chinese Academy of Sciences [2011T2J06]
- Chinese Ministry of Education [212149]
- Key Project of Sichuan Province [09ZA036, 2010SZ0294, 2011JQ0032]
- Intramural Research Program (IRP) of the National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (NIH)
Owing to their unique physical and chemical properties, magnetic iron oxide nanoparticles have become a powerful platform in many diverse aspects of biomedicine, including magnetic resonance imaging, drug and gene delivery, biological sensing, and hyperthermia. However, the biomedical applications of magnetic iron oxide nanoparticles arouse serious concerns about their pharmacokinetics, metabolism, and toxicity. In this review, the updated research on the biomedical applications and potential toxicity of magnetic iron oxide nanoparticles is summarized. Much more effort is required to develop magnetic iron oxide nanoparticles with improved biocompatible surface engineering to achieve minimal toxicity, for various applications in biomedicine.
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