期刊
SMALL
卷 9, 期 6, 页码 920-926出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/smll.201201928
关键词
cancer cells; diagnostics; nanofibers; peptides; self-assembly
类别
资金
- National Natural Science Foundation of China [51125014, 51233003, 21204068]
- Ministry of Science and Technology of China [2011CB606202]
- Fundamental Research Fund for the Central Universities [201120302020004]
A unique peptide nanofibrous indicator (NFI) is fabricated by mixing a borono-peptide with alizarin red S, followed by subsequent binding and self-assembly. The NFI thus obtained exhibits an intense response to sialyl Lewis X tetrasaccharide, which is overexpressed in human hepatocellular carcinoma cell lines. Importantly, this NFI has the capability of specifically recognizing human hepatocellular liver carcinoma (HepG2) cells through the eye-detectable color change resulting from strong binding-induced displacement. This novel technique for cancer cell identification through direct unaided eye judgment will open up an innovative platform for cancer cell detection.
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