期刊
SMALL
卷 8, 期 6, 页码 884-891出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/smll.201101607
关键词
cancer therapy; hydrogels; nanoparticles; tumor delineation; visible contrast
类别
资金
- Guangxi Education Department [201102ZD031]
- [R33CA125297-R33CA125297-03s1]
- [R01 EB007977]
- [R01 EB007977-02s1]
Delineation of tumor margins is a critical and challenging objective during brain cancer surgery. A tumor-targeting deep-blue nanoparticle-based visible contrast agent is described, which, for the first time, offers in vivo tumor-specific visible color staining. This technology thus enables color-guided tumor resection in real time, with no need for extra equipment or special lighting conditions. The visual contrast agent consists of polyacrylamide nanoparticles covalently linked to Coomassie Blue molecules (for nonleachable blue color contrast), which are surface-conjugated with polyethylene glycol and F3 peptides for efficient in vivo circulation and tumor targeting, respectively.
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