期刊
SMALL
卷 9, 期 9-10, 页码 1482-1491出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/smll.201201502
关键词
engineered nanomaterials; quantitative techniques; nanotoxicology; in vivo studies
类别
资金
- Chinese MOST 973 Program [2011CB933400, 2012CB932504]
- National Natural Science Foundation of China [11275215, 11275218, 10905062, 11005118]
Quantifying and imaging the engineered nanomaterials (ENMs) in vivo can provide information on the bio-distribution and fate of ENMs in living systems. A necessary amount of in vivo quantitative data is indispensable to verify the extrapolation from in vitro tests, to modify the predictive models of ENM exposure, and to underpin the risk management strategy for ENMs. However, it remains a challenge to quantitatively assess the bio-distribution of ENMs under realistic exposure, their long-term deposition (especially in non-targeted tissues), their passage across the natural barriers, and the impacts of nanobio interactions on their in vivo behaviors. Some commonly used techniques for in vivo ENM quantification, such as electron microscopy, fluorescence-based detection, atomic spectroscopy, radiotracing, and techniques basing on synchrotron radiation are reviewed, and their technical characteristics, the state of the art, limitations, and future prospects are addressed.
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