期刊
SMALL
卷 8, 期 2, 页码 281-290出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/smll.201101706
关键词
carbon quantum dots; fluorescence; in vivo imaging; biodistribution; toxicology
类别
资金
- National Basic Research Program (973 Program) of China [2012CB932600, 2011CB911002]
- National Natural Science Foundation of China [51132006, 51002100]
- Priority Academic Program Development of Jiangsu Higher Education Institutions
Oxidization of carbon nanotubes by a mixed acid has been utilized as a standard method to functionalize carbon nanomaterials for years. Here, the products obtained from carbon nanotubes and graphite after a mixed-acid treatment are carefully studied. Nearly identical carbon dot (Cdot) products with diameters of 34 nm are produced using this approach from a variety of carbon starting materials, including single-walled carbon nanotubes, multiwalled carbon nanotubes, and graphite. These Cdots exhibit strong yellow fluorescence under UV irradiation and shifted emission peaks as the excitation wavelength is changed. In vivo fluorescence imaging with Cdots is then demonstrated in mouse experiments, by using varied excitation wavelengths including some in the near-infrared (NIR) region. Furthermore, in vivo biodistribution and toxicology of those Cdots in mice over different periods of time are studied; no noticeable signs of toxicity for Cdots to the treated animals are discovered. This work provides a facile method to synthesize Cdots as safe non-heavy-metal-containing fluorescent nanoprobes, promising for applications in biomedical imaging.
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