期刊
SMALL
卷 8, 期 3, 页码 460-467出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/smll.201101909
关键词
nanomotors; magnetic; nanowires; cargo towing; drug delivery
类别
资金
- National Science Foundation [CBET-0853375, CBET-0746285, CMMI-1031239]
- Croucher Foundation
- Programa Becas Complutense del Amo
- Div Of Chem, Bioeng, Env, & Transp Sys
- Directorate For Engineering [746285, 0853375] Funding Source: National Science Foundation
Fuel-free nanomotors are essential for future in-vivo biomedical transport and drug-delivery applications. Herein, the first example of directed delivery of drug-loaded magnetic polymeric particles using magnetically driven flexible nanoswimmers is described. It is demonstrated that flexible magnetic nickelsilver nanoswimmers (56 mu m in length and 200 nm in diameter) are able to transport micrometer particles at high speeds of more than 10 mu m s(-1) (more than 0.2 body lengths per revolution in dimensionless speed). The fundamental mechanism of the cargo-towing ability of these magnetic (fuel-free) nanowire motors is modelled, and the hydrodynamic features of these cargo-loaded motors discussed. The effect of the cargo size on swimming performance is evaluated experimentally and compared to a theoretical model, emphasizing the interplay between hydrodynamic drag forces and boundary actuation. The latter leads to an unusual increase of the propulsion speed at an intermediate particle size. Potential applications of these cargo-towing nanoswimmers are demonstrated by using the directed delivery of drug-loaded microparticles to HeLa cancer cells in biological media. Transport of the drug carriers through a microchannel from the pick-up zone to the release microwell is further illustrated. It is expected that magnetically driven nanoswimmers will provide a new approach for the rapid delivery of target-specific drug carriers to predetermined destinations.
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